Senior Director, Translational Studies & Biomarkers

Company: NextCure Inc
Location: Beltsville
Posted on: August 7, 2022

Job Description:

NextCure , Inc. is a publicly traded clinical-stage biopharmaceutical company located in Beltsville, MD, focused on the discovery and development of first-in-class immune-medicines for the treatment of cancer and other diseases. We are committed to professional development in the context of learning, managing, and developing our employees. We create a unique environment for our employees, providing exposure to various facets of our operations cultivating career growth and development.

We are seeking a highly motivated hire to manage all aspects of NextCure's product development projects. While working in a matrix organization, the successful candidate will thrive and adapt to a fast-paced environment, where they will interface with Development, Research, Clinical, and Business functional units to drive project completion. NextCure is committed to professional development in the context of learning, managing, and developing its employees. We create a unique environment for our employees, providing exposure to various facets of our operations cultivating career growth and development.

Responsibilities

Lead Early Development & Biomarker team to develop and implement translational strategies to achieve project-specific goals and objectives for investigational therapeutics in product pipeline.
Deliver translational science strategy for pre-clinical therapies, including measuring target engagement and pharmacodynamic biomarkers reproducibly and quantifiably to inform and support clinical decisions for selecting therapeutically relevant doses and schedules.
Drive understanding of key cancer pathway interactions, feedback mechanisms, immunological activity, and features of tumor microenvironment in clinical samples to guide rational drug combinations.
Lead external collaborations with partner companies and academic medical institutions to further evaluate therapeutic activity of our novel compounds and refine understanding of their MOA.
Lead in the authoring, coordination and preparation of the translational medicine and mechanistic content of study reports, regulatory filings, project presentations and publications where appropriate.
Provide high-level updates and advice to senior management, including evaluation and interpretation of study data and their potential impact on drug programs and clinical/regulatory strategy.
Build and advance early discovery candidates by leading translational development and in vivo modeling as well as leveraging patients' samples to inform target and drug biology and support clinical development strategy.
Participate in business development meetings, due diligence sessions as needed.
Support cross-functional drug development teams.
Engage in special, value-added projects.

Basic Requirements

PhD and/or MD with experience in drug development.
A minimum of 5 years of relevant industry experience.
In-depth knowledge of oncology disease area biology (solid tumors) and translational science and solid understanding of immunology.

Required Qualifications

Proven track record in planning and executing preclinical/early clinical and late-stage projects.
Ability to drive, manage, execute, and deliver results for complex multi-functional projects.
Working knowledge of product development.
Highly developed problem solving and risk management skills, and attention to detail.
Highly developed collaborative working skills.
Ability to act as an external ambassador and to influence external organizations.
Proven ability to motivate and develop others.
Organized, results-oriented, and proactive and strategic thinker.
Ability to lead and achieve results by influence alone.
Strong knowledge of the key business drivers and considerations in the biotech, pharmaceutical, and /or life science industries.
Excellent organizational skills.
Strong communication skills written and verbal including presentation skills.

NextCure, Inc. offers a competitive salary and benefits package in a scientifically engaged teamwork environment.

NextCure, Inc. is an equal opportunity affirmative action employer and does not discriminate in its selection and employment practices. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, political affiliation, sexual orientation, gender identity, marital status, disability, protected veteran status, genetic information, age, or other legally protected characteristics.

PI186270617

Keywords: NextCure Inc, Baltimore , Senior Director, Translational Studies & Biomarkers, Executive , Beltsville, Maryland