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Biochemist, Receptor Discovery

Company: NextCure, Inc.
Location: Beltsville
Posted on: February 16, 2020

Job Description:

Job Description NextCure is a clinical stage biopharmaceutical company located in Beltsville, MD, and focuses on the discovery and development of novel immunomedicines for the treatment of cancer and other immune-related diseases. We are seeking a highly motivated scientist with a strong background in biochemistry and molecular biology to join our Discovery Research team. NextCure employs multiple function-based screening approaches, termed Functional, Integrated NextCure Discovery for Immuno-Oncology (FIND-IOTM). We are actively developing screening platforms to target additional disease indications. Our goal is to identify novel, first-in-class therapeutic targets. A successful candidate will identify and validate protein-protein interactions to characterize ligand/receptor pairs responsible for mediating intercellular interactions identified by our functional screens. The selected candidate will work in a highly dynamic, proactive, multidisciplinary environment with the goal of rapidly moving novel biological immunomedicines toward the clinic. Responsibilities --- Independently design and perform novel assays to isolate and characterize ligand/receptor pairs and protein complexes in the plasma membrane and extracellular space --- Develop biochemical techniques and identify and compare platforms to facilitate receptor discovery --- Draft research workplans on a target by target basis --- Coordinate with other members of the NextCure team to validate the role of identified protein-pairs in mediating functional intercellular communications --- Manage external collaborations with CROs and academic partners to compliment internal resources and to complete objectives in a timely fashion --- Coordinate tasks across multiple projects and prioritize as appropriate --- Communicate scientific results and conclusions in written reports and oral presentations Required education and experience --- PhD in Biochemistry, Molecular Biology, or a related field --- Postdoctoral experience preferred --- Scientist level and compensation will be commensurate with level of overall experience Qualifications --- Extensive experience in biochemical and protein chemistry techniques (e.g. protein pull-down and crosslinking, chromatography and gel electrophoresis, ForteBio Octet or SPR, SEC-MALS, LC/MS, protein stability assays) --- Hands-on experience with protein pull-down techniques --- Experience with collecting and interpreting mass spectrometry-based proteomics data --- Demonstrated ability to independently investigate, compare, and incorporate new techniques and equipment --- Outstanding project management, organizational and multi-tasking skills --- Strong interpersonal skills, written and oral communication skills, and ability to work in matrix team environment --- Strong publication record NextCure is an Equal Opportunity Employer and offers a competitive salary and benefits package in a scientifically engaged teamwork environment. Qualified candidates should email their resume to

Keywords: NextCure, Inc., Baltimore , Biochemist, Receptor Discovery, Other , Beltsville, Maryland

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