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Associate Scientist/Scientist - Upstream Process Development

Company: Paragon BioServices, Inc.
Location: Baltimore
Posted on: April 18, 2019

Job Description:

Paragon Bioservices is a contract development and manufacturing organization (CDMO) whose focus is the development and manufacturing of cutting-edge biopharmaceuticals. We provide industry-leading GMP development and manufacturing services for cutting-edge biopharmaceuticals such as recombinant viral vectors, next generation vaccines & hard-to-express recombinant proteins and oncolytic viruses. Paragon's scientists, engineers, quality experts, manufacturing operators and program managers are experts working with biologics from research and process development to GMP manufacturing for clinical trials and commercial launch.This individual performs independently and productively as an Upstream Development Associate Scientist and is actively engaged in process and product development within a dynamic project team. Displays strong technical knowledge, initiative and scientific commitment, and makes significant scientific and technical contributions within Process Development Group.Key Responsibilities include, but are not limited to:Has knowledge/expertise relevant to Fermentation and Cell Cultivation Process Development including:

  • Strong understanding and application of aseptic techniques
  • Cell culture handling, cell growth characterization and optimization at different scale
  • Production of material at different scale using various platforms from flasks to stirred-tanks and packed bed bioreactors
  • Understanding of protein biochemistry (protein folding, protein degradation, aggregation, etc.) and experience in optimization of protein expression
  • General analytical methods applicable for proteins (SDS PAGE electrophoresis, western immunoblotting, plaque assay, etc.)
  • Instrument care, maintenance, troubleshooting and data interpretation
  • Document writing, data interpretation, presentation, statistical analysis and trending. Education & Experience:
    • Associate Scientist - B.S. or M.S. in Chemistry, Biology, Life Sciences or Chemical/Biochemical Engineer, 3-7 years of experience in an upstream/cell culture role in the pharmaceutical or biotechnology industry
    • Scientist - M.S. or PhD in Chemistry, Biology, Life Sciences or Chemical/Biochemical Engineer, 3-7 years of experience in an upstream/cell culture role in the pharmaceutical or biotechnology industry
    • Performs hands-on experiments to generate material for production of the recombinant proteins, VLPs, inclusion bodies, etc. from flasks to 200 litre bioreactors
    • Aids in design and execution of the experiments to develop and improve scalable protein production processes utilizing different expression systems with focus on mammalian and insect cell cultures;
    • The ability to work in team oriented environment is essential, as this person will work closely with other members of Process Development Group and participate on multidisciplinary project teams. Paragon Bioservices is proud to be an Equal Employment Opportunity and Affirmative Action employer. We do not discriminate based upon race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics. #LI-EW1

Keywords: Paragon BioServices, Inc., Baltimore , Associate Scientist/Scientist - Upstream Process Development, Other , Baltimore, Maryland

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